Created in 2007, our research team “Handicap and nervous system”, “Handicap Activity Cognition, Health”, is a melting pot uniting different academic specialists in Physical Medicine and Rehabilitation (PRM) focusing on applied research in handicapped patients suffering from various acquired or constitutional neurological diseases. Since 2011, we gained in interdisciplinary with the entry of new team members issued from both social and sport sciences. We were involved in making a success of the Bordeaux University Cognitive Science Master and S2P Doctoral Program. Our research team is engaged in various pathologies such as autism, cerebra-vascular diseases, infectious, inflammatory or genetic disorders, traumatic brain injury, degenerative diseases of the central nervous system or aging processes. Rehabilitation science is an interdisciplinary field that focuses on human function and disability; our field of research covers biomedical and technological aspects as social functioning and developing, improving and restoring the highest possible level of independence. Disablement is now understood as an identifiable variation of human functioning. The three dimensions are called impairments, activity limitations and participation restrictions. The term ‘participation’ is used to identify the nature and extent of a person’s involvement in the basic areas of human life. Our group studies non-pharmacological or technological innovative approaches from acute care to home care in order to allow optimal participation of individuals who have suffered or are still suffering from neurological diseases. Comprehensive assessment and therapies address motor or postural, cognitive, communication and autonomic system impairments. We use mostly cooperative or pooled platforms or low-cost and mini-invasive devices. More recently, we have taken interest in the integrative, real life approach to home conditions, which allows more efficient and individual- designed answers.